The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Identifieur interne : 003F40 ( Main/Exploration ); précédent : 003F39; suivant : 003F41The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
Auteurs : Mark M. Iles [Royaume-Uni] ; D. Timothy Bishop [Royaume-Uni] ; John C. Taylor [Royaume-Uni] ; Nicholas K. Hayward [Australie] ; Myriam Brossard [France] ; Anne E. Cust [Australie] ; Alison M. Dunning [Royaume-Uni] ; Jeffrey E. Lee [États-Unis] ; Eric K. Moses [Australie] ; Lars A. Akslen [Norvège] ; Per A. Andresen [Norvège] ; Marie-Françoise Avril [France] ; Esther Azizi [Israël] ; Giovanna Bianchi Scarra [Italie] ; Kevin M. Brown [États-Unis] ; Tadeusz Debniak ; David E. Elder ; Eitan Friedman [Israël, Italie] ; Paola Ghiorzo [Italie] ; Elizabeth M. Gillanders ; Alisa M. Goldstein [États-Unis] ; Nelleke A. Gruis ; Johan Hansson ; Mark Harland [Royaume-Uni] ; Per Helsing [Norvège] ; Marko Hocevar ; Veronica Höiom ; Christian Ingvar ; Peter A. Kanetsky ; Mariateresa Landi [États-Unis] ; Julie Lang ; G. Mark Lathrop ; Jan Lubinski ; Rona M. Mackie ; Nicholas G. Martin [Australie] ; Anders Molven [Norvège] ; Grant W. Montgomery [Australie] ; Srdjan Novakovic ; H Kan Olsson ; Susana Puig ; Joan Anton Puig-Butille ; Graham L. Radford-Smith [Australie] ; Juliette Randerson-Mor [Royaume-Uni] ; Nienke Van Der Stoep ; Remco Van Doorn ; David C. Whiteman [Australie] ; Stuart Macgregor [Australie] ; Karen A. Pooley ; Sarah V. Ward [Australie] ; Graham J. Mann ; Christopher I. Amos ; Paul D. P. Pharaoh [Royaume-Uni] ; Florence Demenais [France] ; Matthew H. Law [Australie] ; Julia A. Newton Bishop ; Jennifer H. Barrett [Royaume-Uni]Source :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2014.
Descripteurs français
- KwdFr :
- ARN (génétique), Australie, Doigts de zinc (génétique), Europe, Facteurs de confusion (épidémiologie), Helicase (génétique), Humains, Israël, Mutation germinale, Mélanome (génétique), Plan de recherche, Polymorphisme de nucléotide simple, Protéines télomériques (génétique), Ribonucléoprotéines (génétique), Telomerase (génétique), Tumeurs cutanées (génétique), Télomère (génétique), Valeur prédictive des tests, États-Unis d'Amérique.
- MESH :
- génétique : ARN, Doigts de zinc, Helicase, Mélanome, Protéines télomériques, Ribonucléoprotéines, Telomerase, Tumeurs cutanées, Télomère.
- Pascal (Inist)
- Australie, Europe, Facteurs de confusion (épidémiologie), Humains, Israël, Mutation germinale, Mélanome malin, Facteur risque, Plan de recherche, Polymorphisme de nucléotide simple, Risque, Gène, Génétique, Association, Télomère, Longueur, Cancérologie, Valeur prédictive des tests, États-Unis d'Amérique.
- Wicri :
- geographic : Australie, Israël, États-Unis.
- topic : Génétique, Association.
English descriptors
- KwdEn :
- Association, Australia, Cancerology, Confounding Factors (Epidemiology), DNA Helicases (genetics), Europe, Gene, Genetics, Germ-Line Mutation, Humans, Israel, Length, Malignant melanoma, Melanoma (genetics), Polymorphism, Single Nucleotide, Predictive Value of Tests, RNA (genetics), Research Design, Ribonucleoproteins (genetics), Risk, Risk factor, Skin Neoplasms (genetics), Telomerase (genetics), Telomere, Telomere (genetics), Telomere-Binding Proteins (genetics), United States, Zinc Fingers (genetics).
- MESH :
- chemical , genetics : DNA Helicases, RNA, Ribonucleoproteins, Telomerase, Telomere-Binding Proteins.
- geographic : Australia, Europe, Israel, United States.
- genetics : Melanoma, Skin Neoplasms, Telomere, Zinc Fingers.
- Confounding Factors (Epidemiology), Germ-Line Mutation, Humans, Polymorphism, Single Nucleotide, Predictive Value of Tests, Research Design.
Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10-9, two-sided) with melanoma risk.
Url:
Affiliations:
- Australie, France, Israël, Italie, Norvège, Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Nouvelle-Galles du Sud, Yorkshire-et-Humber, Île-de-France, Østlandet
- Cambridge, Leeds, Oslo, Paris, Sydney
- Université Paris-Descartes, Université de Cambridge, Université de Leeds, Université de Sydney
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Le document en format XML
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Brown</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name></author><author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>25 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name></author><author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name></author><author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></author><author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>35 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name></author><author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name></author><author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name></author><author><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>46 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name></author><author><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley</wicri:noRegion></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name></author><author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">15-0030914</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 15-0030914 INIST</idno><idno type="RBID">Pascal:15-0030914</idno><idno type="wicri:Area/PascalFrancis/Corpus">000048</idno><idno type="wicri:Area/PascalFrancis/Curation">005E05</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000070</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000070</idno><idno type="wicri:doubleKey">0027-8874:2014:Iles M:the:effect:on</idno><idno type="wicri:Area/Main/Merge">003F94</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080</idno><idno type="RBID">PMC:4196080</idno><idno type="wicri:Area/Pmc/Corpus">002700</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002700</idno><idno type="wicri:Area/Pmc/Curation">002550</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002550</idno><idno type="wicri:Area/Pmc/Checkpoint">001320</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001320</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003452</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003452</idno><idno type="wicri:Area/PubMed/Curation">003339</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003339</idno><idno type="wicri:Area/PubMed/Checkpoint">003339</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003339</idno><idno type="wicri:Area/Ncbi/Merge">001E14</idno><idno type="wicri:Area/Ncbi/Curation">001E14</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E14</idno><idno type="wicri:doubleKey">0027-8874:2014:Iles M:the:effect:on</idno><idno type="wicri:Area/Main/Merge">003480</idno><idno type="wicri:Area/Main/Curation">003F40</idno><idno type="wicri:Area/Main/Exploration">003F40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length</title><author><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Oncogenomics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney</s1><s3>AUS</s3><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Surgical Oncology, University of Texas MD Anderson Cancer Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, TX</wicri:noRegion></affiliation></author><author><name sortKey="Moses, Eric K" sort="Moses, Eric K" uniqKey="Moses E" first="Eric K." last="Moses">Eric K. Moses</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley</wicri:noRegion></affiliation></author><author><name sortKey="Akslen, Lars A" sort="Akslen, Lars A" uniqKey="Akslen L" first="Lars A." last="Akslen">Lars A. Akslen</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Pathology, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Andresen, Per A" sort="Andresen, Per A" uniqKey="Andresen P" first="Per A." last="Andresen">Per A. Andresen</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Pathology, Molecular Pathology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>11 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Françoise" last="Avril">Marie-Françoise Avril</name><affiliation wicri:level="4"><inist:fA14 i1="19"><s1>Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Department of Dermatology, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation></author><author><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name></author><author><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Oncogenics Unit, Tel Hashomer, Sackler Faculty of Medicine</s1><s2>Tel Aviv</s2><s3>ISR</s3><sZ>13 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Tel Aviv</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Internal Medicine and Medical Specialties, University of Genoa</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital</s1><s2>Genoa</s2><s3>ITA</s3><sZ>14 aut.</sZ><sZ>18 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name></author><author><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. Gruis</name></author><author><name sortKey="Hansson, Johan" sort="Hansson, Johan" uniqKey="Hansson J" first="Johan" last="Hansson">Johan Hansson</name></author><author><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Department of Dermatology, Oslo University Hospital</s1><s2>Rikshospitalet, Oslo</s2><s3>NOR</s3><sZ>25 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Hocevar, Marko" sort="Hocevar, Marko" uniqKey="Hocevar M" first="Marko" last="Hocevar">Marko Hocevar</name></author><author><name sortKey="Hoiom, Veronica" sort="Hoiom, Veronica" uniqKey="Hoiom V" first="Veronica" last="Höiom">Veronica Höiom</name></author><author><name sortKey="Ingvar, Christian" sort="Ingvar, Christian" uniqKey="Ingvar C" first="Christian" last="Ingvar">Christian Ingvar</name></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name></author><author><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name><affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>21 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD</wicri:noRegion></affiliation></author><author><name sortKey="Lang, Julie" sort="Lang, Julie" uniqKey="Lang J" first="Julie" last="Lang">Julie Lang</name></author><author><name sortKey="Lathrop, G Mark" sort="Lathrop, G Mark" uniqKey="Lathrop G" first="G. Mark" last="Lathrop">G. Mark Lathrop</name></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></author><author><name sortKey="Mackie, Rona M" sort="Mackie, Rona M" uniqKey="Mackie R" first="Rona M." last="Mackie">Rona M. Mackie</name></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Genetic Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>35 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>36 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Molecular Epidemiology, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>37 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Novakovic, Srdjan" sort="Novakovic, Srdjan" uniqKey="Novakovic S" first="Srdjan" last="Novakovic">Srdjan Novakovic</name></author><author><name sortKey="Olsson, H Kan" sort="Olsson, H Kan" uniqKey="Olsson H" first="H Kan" last="Olsson">H Kan Olsson</name></author><author><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name></author><author><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name></author><author><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Inflammatory Bowel Diseases Laboratory, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>42 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author><author><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name></author><author><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name></author><author><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Cancer Control Group, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>46 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name></author><author><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia</s1><s2>Crawley</s2><s3>AUS</s3><sZ>9 aut.</sZ><sZ>49 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Crawley</wicri:noRegion></affiliation></author><author><name sortKey="Mann, Graham J" sort="Mann, Graham J" uniqKey="Mann G" first="Graham J." last="Mann">Graham J. Mann</name></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name></author><author><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name><affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>52 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>INSERM, UMR-946, Genetic Variation and Human Diseases Unit</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ><sZ>53 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Statistical Genetics, QIMR Berghofer Medical Research Institute</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>47 aut.</sZ><sZ>54 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Newton Bishop, Julia A" sort="Newton Bishop, Julia A" uniqKey="Newton Bishop J" first="Julia A." last="Newton Bishop">Julia A. Newton Bishop</name></author><author><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds</s1><s2>Leeds</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>24 aut.</sZ><sZ>43 aut.</sZ><sZ>56 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName><orgName type="university">Université de Leeds</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the National Cancer Institute</title><title level="j" type="abbreviated">J. Natl. Cancer Inst.</title><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Australia</term><term>Cancerology</term><term>Confounding Factors (Epidemiology)</term><term>DNA Helicases (genetics)</term><term>Europe</term><term>Gene</term><term>Genetics</term><term>Germ-Line Mutation</term><term>Humans</term><term>Israel</term><term>Length</term><term>Malignant melanoma</term><term>Melanoma (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Predictive Value of Tests</term><term>RNA (genetics)</term><term>Research Design</term><term>Ribonucleoproteins (genetics)</term><term>Risk</term><term>Risk factor</term><term>Skin Neoplasms (genetics)</term><term>Telomerase (genetics)</term><term>Telomere</term><term>Telomere (genetics)</term><term>Telomere-Binding Proteins (genetics)</term><term>United States</term><term>Zinc Fingers (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN (génétique)</term><term>Australie</term><term>Doigts de zinc (génétique)</term><term>Europe</term><term>Facteurs de confusion (épidémiologie)</term><term>Helicase (génétique)</term><term>Humains</term><term>Israël</term><term>Mutation germinale</term><term>Mélanome (génétique)</term><term>Plan de recherche</term><term>Polymorphisme de nucléotide simple</term><term>Protéines télomériques (génétique)</term><term>Ribonucléoprotéines (génétique)</term><term>Telomerase (génétique)</term><term>Tumeurs cutanées (génétique)</term><term>Télomère (génétique)</term><term>Valeur prédictive des tests</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Helicases</term><term>RNA</term><term>Ribonucleoproteins</term><term>Telomerase</term><term>Telomere-Binding Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Australia</term><term>Europe</term><term>Israel</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Melanoma</term><term>Skin Neoplasms</term><term>Telomere</term><term>Zinc Fingers</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN</term><term>Doigts de zinc</term><term>Helicase</term><term>Mélanome</term><term>Protéines télomériques</term><term>Ribonucléoprotéines</term><term>Telomerase</term><term>Tumeurs cutanées</term><term>Télomère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Confounding Factors (Epidemiology)</term><term>Germ-Line Mutation</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Predictive Value of Tests</term><term>Research Design</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Australie</term><term>Europe</term><term>Facteurs de confusion (épidémiologie)</term><term>Humains</term><term>Israël</term><term>Mutation germinale</term><term>Mélanome malin</term><term>Facteur risque</term><term>Plan de recherche</term><term>Polymorphisme de nucléotide simple</term><term>Risque</term><term>Gène</term><term>Génétique</term><term>Association</term><term>Télomère</term><term>Longueur</term><term>Cancérologie</term><term>Valeur prédictive des tests</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term><term>Israël</term><term>États-Unis</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Association</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92×10<sup>-9</sup>, two-sided) with melanoma risk.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Israël</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Nouvelle-Galles du Sud</li><li>Yorkshire-et-Humber</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Cambridge</li><li>Leeds</li><li>Oslo</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Cambridge</li><li>Université de Leeds</li><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><name sortKey="Debniak, Tadeusz" sort="Debniak, Tadeusz" uniqKey="Debniak T" first="Tadeusz" last="Debniak">Tadeusz Debniak</name><name sortKey="Elder, David E" sort="Elder, David E" uniqKey="Elder D" first="David E." last="Elder">David E. Elder</name><name sortKey="Gillanders, Elizabeth M" sort="Gillanders, Elizabeth M" uniqKey="Gillanders E" first="Elizabeth M." last="Gillanders">Elizabeth M. Gillanders</name><name sortKey="Gruis, Nelleke A" sort="Gruis, Nelleke A" uniqKey="Gruis N" first="Nelleke A." last="Gruis">Nelleke A. 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Pooley</name><name sortKey="Puig Butille, Joan Anton" sort="Puig Butille, Joan Anton" uniqKey="Puig Butille J" first="Joan Anton" last="Puig-Butille">Joan Anton Puig-Butille</name><name sortKey="Puig, Susana" sort="Puig, Susana" uniqKey="Puig S" first="Susana" last="Puig">Susana Puig</name><name sortKey="Van Der Stoep, Nienke" sort="Van Der Stoep, Nienke" uniqKey="Van Der Stoep N" first="Nienke" last="Van Der Stoep">Nienke Van Der Stoep</name><name sortKey="Van Doorn, Remco" sort="Van Doorn, Remco" uniqKey="Van Doorn R" first="Remco" last="Van Doorn">Remco Van Doorn</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Iles, Mark M" sort="Iles, Mark M" uniqKey="Iles M" first="Mark M." last="Iles">Mark M. Iles</name></region><name sortKey="Barrett, Jennifer H" sort="Barrett, Jennifer H" uniqKey="Barrett J" first="Jennifer H." last="Barrett">Jennifer H. Barrett</name><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><name sortKey="Harland, Mark" sort="Harland, Mark" uniqKey="Harland M" first="Mark" last="Harland">Mark Harland</name><name sortKey="Pharaoh, Paul D P" sort="Pharaoh, Paul D P" uniqKey="Pharaoh P" first="Paul D. P." last="Pharaoh">Paul D. P. Pharaoh</name><name sortKey="Randerson Mor, Juliette" sort="Randerson Mor, Juliette" uniqKey="Randerson Mor J" first="Juliette" last="Randerson-Mor">Juliette Randerson-Mor</name><name sortKey="Taylor, John C" sort="Taylor, John C" uniqKey="Taylor J" first="John C." last="Taylor">John C. Taylor</name></country><country name="Australie"><noRegion><name sortKey="Hayward, Nicholas K" sort="Hayward, Nicholas K" uniqKey="Hayward N" first="Nicholas K." last="Hayward">Nicholas K. Hayward</name></noRegion><name sortKey="Cust, Anne E" sort="Cust, Anne E" uniqKey="Cust A" first="Anne E." last="Cust">Anne E. Cust</name><name sortKey="Law, Matthew H" sort="Law, Matthew H" uniqKey="Law M" first="Matthew H." last="Law">Matthew H. Law</name><name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><name sortKey="Moses, Eric K" sort="Moses, Eric K" uniqKey="Moses E" first="Eric K." last="Moses">Eric K. Moses</name><name sortKey="Radford Smith, Graham L" sort="Radford Smith, Graham L" uniqKey="Radford Smith G" first="Graham L." last="Radford-Smith">Graham L. Radford-Smith</name><name sortKey="Ward, Sarah V" sort="Ward, Sarah V" uniqKey="Ward S" first="Sarah V." last="Ward">Sarah V. Ward</name><name sortKey="Whiteman, David C" sort="Whiteman, David C" uniqKey="Whiteman D" first="David C." last="Whiteman">David C. Whiteman</name></country><country name="France"><region name="Île-de-France"><name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name></region><name sortKey="Avril, Marie Francoise" sort="Avril, Marie Francoise" uniqKey="Avril M" first="Marie-Françoise" last="Avril">Marie-Françoise Avril</name><name sortKey="Brossard, Myriam" sort="Brossard, Myriam" uniqKey="Brossard M" first="Myriam" last="Brossard">Myriam Brossard</name><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name></country><country name="États-Unis"><noRegion><name sortKey="Lee, Jeffrey E" sort="Lee, Jeffrey E" uniqKey="Lee J" first="Jeffrey E." last="Lee">Jeffrey E. Lee</name></noRegion><name sortKey="Brown, Kevin M" sort="Brown, Kevin M" uniqKey="Brown K" first="Kevin M." last="Brown">Kevin M. Brown</name><name sortKey="Goldstein, Alisa M" sort="Goldstein, Alisa M" uniqKey="Goldstein A" first="Alisa M." last="Goldstein">Alisa M. Goldstein</name><name sortKey="Landi, Mariateresa" sort="Landi, Mariateresa" uniqKey="Landi M" first="Mariateresa" last="Landi">Mariateresa Landi</name></country><country name="Norvège"><noRegion><name sortKey="Akslen, Lars A" sort="Akslen, Lars A" uniqKey="Akslen L" first="Lars A." last="Akslen">Lars A. Akslen</name></noRegion><name sortKey="Akslen, Lars A" sort="Akslen, Lars A" uniqKey="Akslen L" first="Lars A." last="Akslen">Lars A. Akslen</name><name sortKey="Andresen, Per A" sort="Andresen, Per A" uniqKey="Andresen P" first="Per A." last="Andresen">Per A. Andresen</name><name sortKey="Helsing, Per" sort="Helsing, Per" uniqKey="Helsing P" first="Per" last="Helsing">Per Helsing</name><name sortKey="Molven, Anders" sort="Molven, Anders" uniqKey="Molven A" first="Anders" last="Molven">Anders Molven</name></country><country name="Israël"><noRegion><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name></noRegion><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><name sortKey="Azizi, Esther" sort="Azizi, Esther" uniqKey="Azizi E" first="Esther" last="Azizi">Esther Azizi</name><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name></country><country name="Italie"><noRegion><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name></noRegion><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><name sortKey="Ghiorzo, Paola" sort="Ghiorzo, Paola" uniqKey="Ghiorzo P" first="Paola" last="Ghiorzo">Paola Ghiorzo</name><name sortKey="Scarra, Giovanna Bianchi" sort="Scarra, Giovanna Bianchi" uniqKey="Scarra G" first="Giovanna Bianchi" last="Scarra">Giovanna Bianchi Scarra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length
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